

First, make sure that it will indeed be printed on an offset printer because there are many printers who will print on digital printers where the input is expected to be RGB.I don't deal with four color process screen printing very often so I'm reluctant to provide specific instructions but there are lots of resources available online covering CMYK separations within Photoshop. If you're just interested in this at a hobbyist level, you can certainly accomplish this with just Photoshop. It does have some separation functionality built in, but not enough to prep your design for screen printed four color process. Illustrator has plugins available to produce vector halftones (Phantasm), but out of the box it's not the right choice. Within the Adobe Creative Suite, Photoshop is the tool you should use to do this. As others have already mentioned, the print shop you're dealing with will likely do the separations for you (and probably have the powerful software to do so). There are programs specifically designed to do this (AccuRIP, Separation Studio), but they are quite expensive unless you're a print shop then that cost will be difficult to justify.
